Massachusetts State Police are investigating multiple car crash on the Massachusetts Turnpike westbound in Framingham Tuesday about 3 p.m., in which a tanker jackknifed and a car became lodged underneath the tanker.

Preliminary reports from Trooper Thomas McCarthy indicate a 2011 Honda Pilot was travelling in the left travel lane when, for reasons yet to be determined, drifted over into the breakdown lane.

The truck struck the guardrail, coming back across the roadway and striking the right side of a 2006 Western Star tanker trailer, according to State Police. 

The collision caused the tanker trailer to jackknife, blocking all three travel lanes, said a State Police release.

A third vehicle, 2013 Honda CRV that was traveling in the center lane, was unable to stop, and became lodged under the tanker. 

The operator of the Honda Pilot, Andres Pineda, 59, of Hartford Ct., suffered nonlife-threatening injuries and was transported to Leonard Morse Hospital in Natick by Natick EMS. 

The operator of the tanker, Mark Letourneau, 42, of Worcester was not injured.

The operator of the Honda CRV, Trang Pham, 39, of Everett, and her passenger, Lisa Nguyen, 32, of Malden were both transported to Leonard Morse Hospital by Framingham EMS with minor injuries.

All travel lanes westbound were closed for about an hour to allow for rescue operations, an investigation and clean-up of the crash, said a State Police press release. Traffic was backed up for approximately five miles due to the crash. Tolls were waived at Exit 13 in Natick until 5 p.m., while traffic was diverted to Routes 30 and 9.

The crash remains under investigation by Troop E of the Massachusetts State Police and State Police Commercial Vehicle Enforcement Section. 

State Police were assisted by Framingham Fire and Natick Fire and EMS.